Flew coast to coast for work on back-to-back weeks. Slept 4 or 5 hours a night while on the road, ate & drank more/worse than normal and had fair to lousy service in hotels, airports and planes (exception: Canadian security personnel much friendlier than TSA folks - one guy even offered me a chair when I was putting my shoes back on!).
The upside is I got to spend a few 'days-in-the-life' of a traveling consultant, which I appreciate experiencing. I imagine one gets used to it after awhile (one could even grow to love it), but with snow on the US East Coast, inconvenient flight times available from the airlines and productive time lost in meetings and transit, I'd not want to make a habit of it.
Upside #2 - met some fantastic people on both trips. Regardless of how crazy or busy work gets, I have to remind myself that I'm privileged to work with top professionals, many of whom are quietly very decent human beings.